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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of design that include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographic areas. 프라그마틱 슬롯 하는법 of heterogeneity, that is crucial for a pragmatic trial to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they shouldn't be used in lieu for the use of explanation trials.
The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study which includes the recruitment, design, and delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority were conducted in primary-care settings.